At Fort Fairfield, the Tigers earned the 300th career win for coach Larry Gardner.
Whitney McNamee had 14 third-quarter points to help Fort Fairfield turn a six-point halftime lead into a 41-26 lead heading into the final period.
McNamee led the way with 24 points and 12 rebounds, while Nicole Giberson added 14 points and Sydney Churchill chipped in with eight.
Limestone Community School/Maine School of Science and Mathematics was led by Kassee Albert with 12 points, and Alexis Bell and Chelsey Pelkey added eight each.
Fort Fairfield: Bubar 2-0-4, Libby 1-0-2, T. Churchill 1-1-3, N. Giberson 5-4-14, S. Churchill 1-5-8, McNamee 11-2-24, K. Giberson, Goshorn, Bouchard, Maynard, Jellison
LCS/MSSM: D. Pelkey 0-1-1, Williams 1-0-2, Ka. Albert 6-0-12, Bell 3-2-8, C. Pelkey 2-4-8, Contafio 1-2-5, Ke. ALbert 1-0-2, Hopkins
LCS/MSSM 6 17 26 38
Fort Fairfield 7 23 41 55