At Richmond, Tristan Richards scored his first goal 14 minutes into the game, then converted a direct kick with 26 minutes to play in the second half, helping the fourth-seeded Lakers pull the upset.
Henry Hersey scored the other goal for 9-7 Greenville and Corey Henderson made seven saves on nine shots.
Randy Moody scored the goals for No. 1 Richmond (14-1), with both coming on headers. Xavier Trask provided an assist and Dustin Sullivan made nine saves on 12 shots.