BOSTON — David Ortiz hit a pair of two-run homers, including the 400th of his Boston career, and drove in a career-high-tying six runs to power the Red Sox to a 10-7, comeback victory over the Houston Astros on Saturday night.
Right fielder Daniel Nava added three hits and two RBIs as the Red Sox won for the fifth time in six games.
Ortiz belted his first homer off Houston starter Brad Peacock in the third inning, becoming the 25th player in major league history to hit 400 with one team, and only the third to do so with Boston, joining Hall of Famers Ted Williams (521) and Carl Yastrzemski (452).
The homer cut Houston’s lead to 5-3.
Ortiz’s second shot of the game off Peacock, a line drive that curled just inside the right field foul pole for his 28th of the season and 459th of his decorated career, ignited the surge as Boston crept within 6-5.
The Red Sox tied it later that inning when left fielder Yoenis Cespedes reached on an error by first baseman Jon Singleton — who dropped the high fly ball — and scored on Nava’s single. Center fielder Jackie Bradley Jr.’s sacrifice fly gave Boston its first lead of the game.
Ortiz then came to the plate in the eighth with the bases loaded, and the designated hitter delivered two more runs with a double to left-center, eventually exiting for a pinch runner to a standing ovation from the Fenway faithful.
Cespedes added an RBI single to make it 10-6.
Alex Wilson (1-0) tossed 2 1/3 perfect relief innings for the win. Boston closer Koji Uehara gave up a solo homer to Houston catcher Jason Castro in the ninth inning in a non-save situation.
Houston reliever Josh Fields (2-6) retired only two of the five batters he faced in the decisive fifth inning.
Designated hitter Chris Carter hit his 29th home run of the season.
Peacock allowed six runs (five earned) on seven hits and two walks over 4 1/3 innings, striking out three.
Boston starter Rubby De La Rosa lasted just four innings. The right-hander gave up six runs on nine hits with four walks and two strikeouts as his home ERA ballooned from 1.97 to 3.25.
Houston jumped on him from the start, taking a 2-0 lead in the first on an RBI single by center fielder Dexter Fowler and an RBI groundout by Singleton. The Astros made it 3-0 in the second on Carter’s sacrifice fly.
After Boston made it a two-run game on Nava’s RBI double, Houston stretched the lead to 5-1 in the third on third baseman Gregorio Petit’s two-run double.
Ortiz’s first homer, a blast to straightaway center, cut the deficit to two, but Carter belted a solo shot an inning later to make it 6-3.
NOTES: First-round draft picks Dominique Easley of the New England Patriots and Marcus Smart of the Boston Celtics threw out the ceremonial first pitches. … Boston C David Ross is slated to be activated off the disabled list early this week. Ross has been sidelined since Aug. 2 with plantar fasciitis in his right foot. … Red Sox OF Allen Craig, on the DL with a sprained left foot, will begin a rehab assignment with Triple-A Pawtucket on Monday. … Boston 2B Dustin Pedroia was back in the lineup after leaving Friday’s game when he fouled a ball off his right foot. … Houston RHP Collin McHugh (5-9, 3.08 ERA) opposes Boston RHP Joe Kelly (0-0, 2.08) on Sunday in the finale of the three-game series.