May 28, 2018
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Scientists say genetics of world’s oldest man, 115, could help treat diseases

Guinness World Records | BDN
Guinness World Records | BDN
In this photo taken Oct. 15, 2012, Jiroemon Kimura poses with Craig Glenday, Guinness World Records editor-in-chief, after Kimura was presented with the certificate of the world's oldest living man at his home in Kyotango City, Kyoto Prefecture, Japan.
By Kanoko Matsuyama and Meg Tirrell, Bloomberg News

TOKYO — Jiroemon Kimura, who became the world’s oldest man on record in late December, can thank a combination of luck early in life and, later, good genes for surviving seven decades longer than most of his peers.

Kimura, a former postman who is 115 years old and still greets visitors with a warm smile, dodged childhood killers such as tuberculosis and pneumonia that kept life expectancy in Japan to 44 years around the time he was born in 1897. As an adult living in the town of Tango, he had no major illnesses, his granddaughter-in-law Eiko Kimura said in an interview. He followed sumo wrestling on television and read two newspapers a day until the last few years, she said.

As Kimura ages, his DNA is giving him an edge. Scientists say specific genes that protect against heart disease, cancer and other old-age ailments foster longevity. Knowing the biological mechanisms involved may provide clues to counter a rising tide of non-communicable diseases predicted to cost the global economy $47 trillion over the next 20 years.

“Getting the right combination is like winning the lottery,” said Thomas Perls, director of the New England Centenarian Study at Boston University. Some of Kimura’s genes “are likely protective against damaging cellular processes that contribute to aging and even protective against genetic variants that may not be good for him.”

Genetic factors may account for about 30 percent of a person’s chances of living to their late 80s, with behavior and the environment contributing the remainder, according to Perls. The reverse is true in people who survive to 105 years, when genetic influences become more significant, he said.

As people age, cells accumulate potentially harmful mutations as mechanisms to repair defective DNA become less efficient, said Dario Alessi, a cell biologist at the University of Dundee in Scotland. Kimura may have no major disease-causing mutations or a superior ability to repair defective genes, he said. Scientists are making conclusions about Kimura based on the medical history of the centenarian and his relatives; they haven’t studied his genome.

Another cellular aging mechanism involves DNA sequences at the ends of chromosomes known as telomeres which help determine how often cells can divide. While telomere lengths vary from person to person at the time of birth, centenarians tend to have longer ones, said Carol Greider, professor of molecular biology and genetics at Johns Hopkins University in Baltimore, who won a Nobel prize in 2009 for her research.

Those born with the shortest telomeres tend to suffer at higher rates from age-related degenerative diseases, she said, adding that Kimura may have long telomeres.

Kimura has defied the odds against his gender as well. Men make up only 15 percent of centenarians, according to Boston University’s Perls.

Kimura, who became the world’s oldest person after Dina Manfredini of Iowa died last month, is among 22 Japanese listed on the world’s 64 oldest people compiled by the Los Angeles-based Gerontology Research Group.

Born on April 19, 1897, the third of six children to a couple of rice and vegetable farmers, Kimura married his neighbor, Yae, and helped deliver his town’s mail for more than 40 years, during a period marked by malnutrition-causing food shortages. He also spent several months in a government communication unit in Korea in 1920 during Japan’s occupation.

Kimura’s main health challenges have been cataracts and a bout of pneumonia years ago, said Eiko Kimura, the granddaughter-in-law who cares for him in the two-story wooden house he built in the 1960s.

Kimura’s motto is “eat light to live long,” and says the key to his longevity is to be a healthy, small eater, Guinness World Records said in a Dec. 28 statement in which it acknowledged his status as the oldest male on record and oldest living person.

“Grandpa is positive and optimistic,” Eiko said. “He becomes cheerful when he has guests. Even when he falls ill, I can tell he’ll recover.”

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