SAN FRANCISCO — The New York Giants gave the San Francisco 49ers another reason to simmer.
Antrel Rolle intercepted two passes by Alex Smith, Prince Amukamara picked off another and the Giants shut down San Francisco in a 26-3 victory over the 49ers on Sunday in a rematch of last season’s NFC championship game.
After outscoring the Bills and Jets by a combined 79-3 the last two weeks, the 49ers (4-2) met their match again with Eli Manning and New York’s top team. No overtime needed this time, and not much of Manning either.
Manning threw for 193 yards and one touchdown, Ahmad Bradshaw ran for 116 yards and a score and New York (4-2) rode a dominant defense and four fields by Lawrence Tynes to hand outspoken 49ers coach Jim Harbaugh the most lopsided loss of his tenure.
What a San Francisco treat.
The Giants grinded out a 20-17 overtime win at rain-soaked Candlestick Park on Jan. 22, capitalizing on two fumbles by fill-in returner Kyle Williams en route to another Super Bowl title over the Patriots. All week some San Francisco players talked about “unfinished business,” and Harbaugh added to the hype when he fired back a strongly worded statement criticizing Giants offensive coordinator Kevin Gilbride for saying All-Pro defensive end Justin Smith often “gets away with murder” holding linemen.
For all the hoopla, the rematch was never close.
Amukamara’s interception in the second quarter started a surge of New York offense. Smith, who wore tape around his sprained middle finger, lofted the pass too high and allowed Amukamara to leap underneath the ball before tight end Delanie Walker even had a chance at the Giants 33.
At one point in the first half, Manning completed eight consecutive passes for 142 yards and had the usually stout San Francisco defense out of sorts. Domenik Hixon caught passes of 39 and 16 yards on consecutive third downs, and Victor Cruz followed with a 6-yard touchdown catch and his usual salsa dance in the end zone to give the Giants a 7-3 lead in the second quarter.
New York’s next drive stalled and Tynes kicked a 34-yard field goal to go ahead 10-3. Tarell Brown blocked a 40-yard attempt by Tynes, San Francisco took over with 8 seconds left before half and wildcat quarterback Colin Kaepernick completed a 36-yard pass to Mario Manningham — the former Giant — before David Akers missed wide left from 52 yards as time expired.
It was the seventh time in Smith’s career the 2005 No. 1 overall pick threw three interceptions. The last time came in a 27-13 loss at Philadelphia on Dec. 20, 2009.
LIONS 26, EAGLES 23: Jason Hanson kicked a 45-yard field goal in overtime and the Detroit Lions rallied from a 10-point fourth-quarter deficit to beat the Eagles.
Held in check most of the game, Matthew Stafford led Detroit to 17 points in the fourth quarter. He threw a TD pass and ran for a score.
Detroit had two shots from the Eagles 1 after a pass interference penalty on Colt Anderson with 13 seconds left in regulation. But Stafford misfired on both passes and Hanson kicked a 19-yard field goal to send it to overtime.
The Lions (2-3) sacked Michael Vick on the first two plays of the extra quarter, forced a punt out of the end zone and started at midfield.
Stafford hit Calvin Johnson for a 17-yard gain to the Eagles 27 on first-and-20. A few plays later, Hanson nailed the game-winner.
The Eagles (3-3) head into their bye week with two straight losses.
REDSKINS 38, VIKINGS 26: Robert Griffin III ran for 138 yards and two touchdowns, including a 76-yard scamper with 2:43 to play, and Washington snapped an eight-game home losing streak.
One week after he left the game early with his first NFL concussion, Griffin also completed 17 of 22 passes for 182 yards with one touchdown and one interception.
The Redskins (3-3) feasted on a Minnesota team that had not allowed more than 23 points in a game this season. Minnesota’s three-game winning streak ended. The Vikings are 4-2.
Minnesota held an early 9-0 lead but paid the price for getting field goals instead of touchdowns in the red zone.
Christian Ponder completed 35 of 52 passes for 352 yards.
FALCONS 23, RAIDERS 20: Matt Bryant kicked his second game-winning field goal in three weeks, a 55-yarder with 1 second remaining.
Overcoming Matt Ryan’s three interceptions, the Falcons (6-0) extended the best start in franchise history. But it wasn’t easy against the pesky Raiders (1-4).
Atlanta pulled ahead when Asante Samuel returned an interception 79 yards for a touchdown with 2:40 remaining, only to wind up tied again when Carson Palmer led Oakland down the field for a tying score. Darren McFadden powered in from the 2 with 40 seconds left.
That was just enough time for Ryan and Bryant to pull off another fourth-quarter victory. Ryan completed four passes to set up the winning kick.
BILLS 19, CARDINALS 16 OT: Jairus Byrd’s second interception of the game set up Rian Lindell’s 25-yard field goal 3:50 into overtime.
The loss ended Arizona’s eight-game home winning streak.
Byrd picked off a pass from John Skelton, who had replaced the injured Kevin Kolb, and returned it 29 yards to the Arizona 6 to set up the winning kick.
Arizona’s Jay Feely kicked a franchise-record 61-yard field goal with 1:09 left in regulation to tie it 16-16, but his 38-yard attempt to win it as the fourth quarter ended careened off the left upright. Feely says someone tipped the attempt.
The Cardinals (4-2) lost their second in a row after a 4-0 start. The Bills (3-3) won after allowing 1,201 yards and 97 points in their previous two games.
RAVENS 31, COWBOYS 29: Jacoby Jones tied an NFL record with a 108-yard kickoff return and Baltimore won its 14th straight regular-season home game
Dallas ran for 227 yards, most ever against the Ravens, and totaled 481 yards offense. But the Cowboys (2-3) missed a 2-point conversion after closing to two points with 32 seconds left.
Dallas recovered the onside kick, and Dan Bailey was wide left on a 51-yard field goal try with 6 seconds left.
Ray Rice scored two touchdowns and Joe Flacco threw for a score to help the Ravens (5-1) secure their fourth consecutive victory and enhance their grip on first place in the AFC North. Baltimore’s home winning streak is the longest current run in the NFL.
BUCCANEERS 38, CHIEFS 10: Josh Freeman threw for 328 yards and three touchdowns and Ronde Barber scored on a 78-yard interception return.
Freeman teamed with Mike Williams on a 62-yard scoring play in the first quarter and threw TD passes of 19 and 17 yards to Vincent Jackson in the second half as the Bucs (2-3) stopped a three-game losing streak.
The Bucs intercepted Brady Quinn — starting for the Matt Cassel (concussion) — twice in the Kansas City quarterback’s first start in nearly three years. They also limited NFL rushing leader Jamaal Charles to 40 yards on 12 carries.
BROWNS 34, BENGALS 24: Rookie Brandon Weeden threw two touchdown passes and Cleveland snapped an 11-game losing streak that dated to last season.
Cleveland had not won since Nov. 20, matching a franchise record for consecutive losses. But for the first time this season everything fell into place for the Browns (1-5).
Montario Hardesty, filling in for injured rookie Trent Richardson, scored on a 1-yard plunge and cornerback Sheldon Brown intercepted Andy Dalton and returned it 19 yards for a touchdown in the fourth quarter as the Browns outscored the Bengals (3-3) in the second half 27-10.
DOLPHINS 17, RAMS 14: Ryan Tannehill threw two touchdown passes and Miami withstood a late rally.
The Rams faced a fourth-and-8 at the Miami 48-yard line with 30 seconds left, and rather than go for a first down, coach Jeff Fisher sent out rookie Greg Zuerlein to try a 66-yard field goal, which missed wide left.
Zuerlein made two field goals to improve to 15 for 15 this season, but then missed three times in a row, including from 48 and 32 yards in the first half.
The Rams outgained the Dolphins 461-209.
Both teams are 3-3. Fisher lost to the team that courted him in January, when he chose the Rams job instead.