June 21, 2018
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Drug shown to dramatically help melanoma patients in tests

By Rob Stein, The Washington Post

An experimental drug designed to attack a tumor’s genetic trigger has produced dramatic results in patients with advanced melanoma, one of the deadliest and most impervious cancers, researchers reported Sunday.

The drug — known so far only by its technical names vemurafenib and PLX4032 — made tumors shrink significantly in nearly half of patients studied, reduced the risk the disease would progress by nearly two-thirds and slashed the chances of dying by 63 percent.

The eagerly awaited results provide some of the clearest evidence yet that drugs created to pinpoint molecular characteristics of patients’ cancers can produce unprecedented benefits.

“This is really a huge step toward personalized care in melanoma,” said Paul Chapman of the Memorial Sloan-Kettering Cancer Center in New York, who led the study. “This is the first successful melanoma treatment tailored to patients who carry a specific gene mutation in their tumor.”

Chapman and others cautioned that the drug is not a cure and many patients’ tumors appear to become resistant to the treatment, making it unclear how long it may prolong their lives. But for a disease that has been so difficult to treat, the results are striking.

“This is really unprecedented for patients with melanoma,” said Lynn Schuchter of the University of Pennsylvania, who moderated the panel where the results were presented at the annual meeting of the American Society of Clinical Oncology in Chicago. “It just changes the landscape for patients.”

Conventional chemotherapy usually works by killing any rapidly dividing cells. Because cancer cells proliferate quickly, chemo drugs can shrink tumors. But they also kill healthy cells, which is why they cause nausea, vomiting, hair loss and other often debilitating side effects.

PLX4032 is one of a new generation of drugs that researchers hope will be more effective and less toxic because they zero in on genetic characteristics of cancer cells that are not found in healthy cells.

“Whereas in the past we had to use a shotgun approach to cancer treatment — treating many to help a few — we now are on the cusp of a new era in cancer treatment where we can use these predictive tests to focus our treatments on those patients who are most likely to respond to a specific cancer treatment,” said J. Leonard Lichtenfeld, deputy chief medical officer at the American Cancer  Society .

Melanoma strikes more than 68,000 Americans each year and kills about 8,700. Despite decades of research, it remains one of deadliest malignancies with few treatment options.

“This is a very exciting and important study in a disease that for decades has resisted any meaningful treatment when it has spread through the body,” Lichtenfeld said.

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